Just give me one thing I can play for.
Disco boys on bicycles.
So what if too many times we have been here, both
Poetic Retrospective
The Weather votes for Kelly Clarkson."So, did you go to any raves in Canada?"
"Uh, no."
"So you don't have any drugs"
"No, we don't have any drugs"
"No, drugs?"
"Nope, definitely no drugs."
"So you have drugs?"
"Um....no, we don't have any drugs."
long pause, as he stares at the computer inside his booth.
"You guys got any ex?"
"Definitely not."
"Ok, have a nice day."
Granted, my companion and I did have a trunk full of vinyl records, but our man at the border seemed far too interested in whether we had anything capable of alleviating the symptoms of Parkinson's in mice. Because, as it turns out, a new study shows that this is exactly what the drug commonly know as ecstasy is capable of.
Chemically reffered to as methylenedioxymehtamphetamine (MDMA), ecstasy made a name for itself during the rise of rave culture in the mid 90's as a potent emotional stimulant. MDMA acts by triggering the release of three neurotransmitters in the brain, dopamine, norepinephrine and most notably serotonin. Studies have shown that extended use of the drug can cause desensitization of serotonin release, which can lead to long-standing depression as well as memory impairment.
In a recent study, biologists at Duke University administered MDMA to mice that were unable to produce dopamine due to a genetic alteration. Low levels of dopamine are a hallmark of the brain chemistry accompanying Parkinson's, in addition to the external characteristics of limb stiffness and muscle tremors. In comparison to a number of other compounds, MDMA fared the best in alleviating the Parkinson's like symptoms of the mice. Interestingly, the club drug did not actually raise dopamine levels, apparently acting through some other, as yet unknown mechanism. The study leaders insist that these findings should not be used to support self medication, and are looking for a similar compound that might promote the same effects. They are also having a big party tonight to celebrate their new paper, you should stop by.
All the way across the Atlantic, astounding facts are emerging concerning how much cocaine Italians do. In a study published this week, investigators reported the amount of cocaine being consumed by the 5 million people that live along the Po river, including those in nearby cities Milan and Genoa. The team took small samples from sewage and river water and measured the amount of Benzolycgonine in them, a key metabolite excreted in the urine of cocaine users. After scaling up the amount of metabolite to reflect the total daily waterflow in the areas they sampled, the team determined that approxamitley 400,000 lines are peed into the river every day. For all the Tony Montanas reading, that's about 4 keez mang. According to Ettore Zuccato, the leader of the study, "It's higher than we were expecting."
In a final report to tie together this week in drugs in a nice little rubber band around the upper arm, last night I watched Neil Patrick Harris steal a car on E and do coke off a naked stripper's butt on my television screen.